Novo Nordisk
Clayton, NC, U.S.

Novo Nordisk API Manufacturing Facility

Fluor was awarded an engineering, procurement, construction and construction management contract by Novo Nordisk for its new Active Pharmaceutical Ingredient (API) manufacturing facility in Clayton, North Carolina. Fluor previously provided basic design services for this project.

The facility will produce pharmaceutical ingredients for diabetes medicines, providing modern treatment to people with diabetes in the U.S. and around the world. The world-class facility is the single largest life sciences facility investment in North Carolina’s history, as well as Novo Nordisk’s largest project. Nearly 2,500 craft employees and subcontractor jobs are expected at peak construction, with about 700 jobs expected at the facility upon completion.


Client's Challenge

Novo Nordisk is a global healthcare company with more than 90 years of innovation and leadership in diabetes care, as well as care for other serious chronic conditions including hemophilia, growth disorders and obesity. Novo Nordisk is headquartered in Denmark and employs approximately 42,000 people in 77 countries. The company markets its products in more than 165 countries.

The new facility in Clayton, North Carolina will be located adjacent to Novo Nordisk’s existing fill/finish facility there. The new facility will produce active pharmaceutical ingredients for a range of Novo Nordisk's current and future GLP-1 and already marketed intermediates. Process activities will include fermentation, recovery and purification.


Fluor's Solution

Fluor is providing engineering, procurement, construction and construction management, and commissioning and pre-qualification for Novo Nordisk’s API manufacturing facility in North Carolina.

Once complete, the new facility will measure 800,000 square feet and have a footprint of 85 acres – the equivalent to approximately seven football fields. The Greenfield facility will include a Central Utilities Building (CUB), offices and labs, a warehouse, and three manufacturing plants.

Fluor’s Greenville, South Carolina office is leading the project with support from its office in Gliwice, Poland. The project team will utilize Fluor Site ConnectSM capabilities, our construction automation tool used on mobile devices in the field to expedite project work flow, and external industry partners to advance a paperless execution approach.

A ceremonial groundbreaking marked the beginning of construction activities in March 2016. In June 2019, the North Carolina Department of Labor recognized the project team for achieving three million work hours without a lost-time incident.


Fluor has completed its scope of work on the project. The facility is awaiting final regulatory approvals to begin operation.