Fluor was selected to execute the LSM project based on our demonstrated capabilities in the biotech industry and proven performance on prior Biogen projects. This project highlighted our expertise; especially in the areas of process technology, modular construction, and validation. Innovative advances for the LSM project included large-scale bioreactors, large-scale purification, buffer concentrates with online dilution, and extensive use of "unclassified" space for processing.
The project logistics were extremely complex. Fluor simultaneously coordinated the design and assembly of modules from three equipment supplier sites. Many of the construction workers did not speak English, so site signage and training materials were translated to ensure personnel understood what was expected of them in the areas of project execution and safety. The true success of Fluor’s team effort culminated in delivering the project to Biogen under budget and one month ahead of schedule.
The LSM project also demonstrated Fluor's focus on safety as a core company value. The LSM site celebrated 2 million hours without a lost workday case. Additionally, this outstanding effort contributed to Fluor achieving 5 million safe work hours in North Carolina and earning Fluor the North Carolina Department of Labor's highest safety award.
Biogen Idec selected Fluor for this important biotech project because of its successful performance on other projects dating back to the early 1990s. Fluor understood Biogen Idec's critical need for an accelerated schedule to get new products to market and worked closely with all stakeholders to meet the client's requirements.
The use of modular construction for the LSM facility was a first in the biotech industry. The modules had to meet the FDA's Current Good Manufacturing Practices (CGMP), and Fluor implemented stringent methodologies for coordination and management during module design, fabrication, and delivery.
In addition to delivering the project one month ahead of schedule, Fluor also completed the project with an excellent safety record. North Carolina's Department of Labor recognized Fluor with the state’s highest safety award.